NCOA4

Across TCGA cell cohorts, NCOA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,011 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NCOA4-associated GO terms across cancer lineages are Protein localization to endosome, Melanosome assembly, and Endosome organization. Each is linked with NCOA4 in more than 8 cancer types. Because this analysis shows association rather than direction, both NCOA4-to-partner and partner-to-NCOA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to endosome grouped by NCOA4-low versus NCOA4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NCOA4→partner) and Y-score (partner→NCOA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein localization to endosome →	+0.259	+1.091	<.001	<.001	3	9
OVARY	Melanosome assembly →	+0.068	+0.588	.005	.002	3	9
SOFT_TISSUE	Endosome organization →	+0.076	+0.816	<.001	<.001	3	9
BLOOD_Lymphoma	Double-strand break repair via classical nonhomologous end joining →	+0.064	+0.779	<.001	<.001	3	9
BONE	Response to acid chemical →	+0.106	+0.838	<.001	.005	3	8
BREAST	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.074	+0.711	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,011 associations by consensus.

Protein localization to endosome by NCOA4 expression — BONE

Explore this box plot interactively →