NCOA4

Across TCGA cell cohorts, NCOA4 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible NCOA4-associated genes across cancer lineages are R3HDML, KRTAP3-3, and GJD2. Each is linked with NCOA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCOA4-to-partner and partner-to-NCOA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HDML grouped by NCOA4-low versus NCOA4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCOA4→partner) and Y-score (partner→NCOA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	R3HDML →	+0.484	+4.199	<.001	.007	3	1
BLOOD_Leukemia	KRTAP3-3 →	+0.043	+6.569	<.001	<.001	3	1
LARGE_INTESTINE	GJD2 →	+0.004	+4.437	<.001	.004	3	1
LUNG_SCLC	PRAC1 →	+2.537	+5.029	.001	.006	3	1
LUNG_SCLC	DIRC1 →	+0.053	+5.643	<.001	.002	3	1
LUNG_SCLC	OR8B8 →	+0.066	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

R3HDML by NCOA4 expression — BREAST

Explore this box plot interactively →