NCOA4

Across TCGA cell cohorts, NCOA4 mutation is significantly associated with the mutation status of many other genes, with 1,483 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NCOA4-associated genes across cancer lineages are TBC1D2, IKBKE, and ADGRG7. Each is linked with NCOA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both NCOA4-to-partner and partner-to-NCOA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D2 grouped by NCOA4-low versus NCOA4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCOA4→partner) and Y-score (partner→NCOA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TBC1D2 →	+4.857	+4.297	.009	.009	1	3
BLOOD_Leukemia	IKBKE →	+4.000	+5.050	.008	.008	1	3
BLOOD_Leukemia	ADGRG7 →	+4.000	+5.050	.008	.008	1	3
LARGE_INTESTINE	TCF25 →	+3.329	+3.799	.005	.005	1	3
BLOOD_Leukemia	KCTD15 →	+4.321	+5.285	.005	.005	1	3
LARGE_INTESTINE	NUAK2 →	+3.007	+3.584	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,483 associations by consensus.

TBC1D2 by NCOA4 expression — BREAST

Explore this box plot interactively →