NCOA2

Across TCGA patient cohorts, NCOA2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCOA2-associated genes across cancer lineages are ASNS, Cyclin-B1, and ATM. Each is linked with NCOA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NCOA2-to-partner and partner-to-NCOA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by NCOA2-low versus NCOA2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCOA2→partner) and Y-score (partner→NCOA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ASNS →	+0.446	+2.179	.034	.035	3	4
UCEC	Cyclin-B1 →	+0.736	+2.273	<.001	<.001	3	3
UCEC	ATM →	-0.500	-1.754	<.001	.001	3	3
UCEC	CDK1 →	+0.114	+1.247	.012	.041	3	3
LUSC	Dvl3 →	+0.268	+2.179	.003	.035	3	2
UCEC	STAT3_pY705 →	-0.321	-1.321	<.001	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ASNS by NCOA2 expression — LUSC

Explore this box plot interactively →