NCOA1

Across TCGA pan-cancer cohorts, NCOA1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NCOA1 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NCOA1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NCOA1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where NCOA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.705	0.938	.009	32	view →
PDAC	OS	Quartile	All	0.590	0.362	.006	17	view →
LUAD	DFS	Median	II,III,IV	0.690	0.966	.005	15	view →
CCRCC	OS	Quartile	III,IV	1.000	0.586	.025	4	view →
LSCC	OS	Tertile	All	1.000	0.812	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NCOA1–HNSC (OS)

Open the HNSC breakdown →