NCOA1

Across TCGA pan-cancer cohorts, NCOA1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of NCOA1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where NCOA1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NCOA1 is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, HNSC, and CCRCC are the cancer types where NCOA1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NCOA1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.492	<.001	9	view →
HNSC	All	III,IV	−0.351	<.001	8	view →
CCRCC	All	All	−0.156	<.001	7	view →
LSCC	Male	II,III,IV	−0.133	<.001	4	view →
OV	All	All	−0.372	.031	2	view →
COAD	Female	All	−0.217	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

NCOA1–LUAD

Open the LUAD breakdown →