NCOA1

Across TCGA patient cohorts, NCOA1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCOA1-associated genes across cancer lineages are ATM, MEK1, and PDCD4. Each is linked with NCOA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NCOA1-to-partner and partner-to-NCOA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NCOA1-low versus NCOA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCOA1→partner) and Y-score (partner→NCOA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.810	-3.161	<.001	.019	2	5
UCEC	MEK1 →	+0.308	+1.836	.002	.001	3	3
UCEC	PDCD4 →	-0.452	-1.206	<.001	.009	3	3
UCEC	Rad50 →	-0.135	-1.266	.043	.049	3	3
UCEC	ASNS →	+0.335	+1.925	<.001	.004	3	3
UCEC	Caspase-7-cleavedD198 →	+0.480	+2.000	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

ATM by NCOA1 expression — COAD

Explore this box plot interactively →