NCOA1

Across TCGA cell cohorts, NCOA1 mutation is significantly associated with the RNA expression of many other genes, with 256 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NCOA1-associated genes across cancer lineages are C1orf105, KRTAP19-3, and OR2J2. Each is linked with NCOA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCOA1-to-partner and partner-to-NCOA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf105 grouped by NCOA1-low versus NCOA1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCOA1→partner) and Y-score (partner→NCOA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	C1orf105 →	+0.622	+3.628	<.001	.009	3	2
LUNG_SCLC	KRTAP19-3 →	+0.267	+4.614	<.001	<.001	3	2
URINARY_TRACT	OR2J2 →	+0.013	+5.087	<.001	.004	3	2
CNS	F9 →	+0.021	+4.321	<.001	.009	3	2
CNS	TRIM48 →	+0.235	+4.472	<.001	.004	3	2
CNS	UCMA →	+0.207	+4.754	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 256 associations by consensus.

C1orf105 by NCOA1 expression — LUNG_SCLC

Explore this box plot interactively →