NCLN

Across TCGA patient cohorts, NCLN RNA expression is significantly associated with the protein abundance of many other proteins, with 12,639 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible NCLN-associated proteins across cancer lineages are DNMT1_S714, NOL6, and UTP4. Each is linked with NCLN in more than 6 cancer types. Because this analysis shows association rather than direction, both NCLN-to-partner and partner-to-NCLN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NCLN versus DNMT1_S714 in LUAD, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NCLN→partner) and Y-score (partner→NCLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DNMT1_S714 →	+0.828	+0.554	<.001	<.001	3	7
LSCC	NOL6 →	+0.301	+0.368	<.001	.001	3	5
LSCC	UTP4 →	+0.306	+0.472	<.001	<.001	3	5
LSCC	RAVER1 →	+0.243	+0.595	<.001	<.001	3	5
COAD	CHAF1A_S141 →	+0.710	+0.464	.001	.003	3	5
LSCC	CHAF1B →	+0.602	+0.586	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,639 associations by consensus.

NCLN vs DNMT1_S714 — LUAD

Explore this scatter interactively →