NCLN

Across TCGA patient cohorts, NCLN protein abundance is significantly associated with the RNA expression of many other genes, with 11,810 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NCLN-associated genes across cancer lineages are CHRDL1, ADCY5, and NRXN2. Each is linked with NCLN in more than 5 cancer types. Because this analysis shows association rather than direction, both NCLN-to-partner and partner-to-NCLN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NCLN versus CHRDL1 in BRCA, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCLN→partner) and Y-score (partner→NCLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHRDL1 →	-1.591	-0.323	<.001	<.001	3	6
CCRCC	ADCY5 →	-1.070	-0.239	<.001	.003	3	6
GBM	NRXN2 →	-0.938	-0.144	<.001	<.001	3	5
UCEC	SPARCL1 →	-1.300	-0.485	<.001	<.001	3	5
COAD	MYRIP →	-0.846	-0.126	.001	.005	3	5
UCEC	ZNF728 →	-0.651	-0.377	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,810 associations by consensus.

NCLN vs CHRDL1 — BRCA

Explore this scatter interactively →