NCLN

Across TCGA patient cohorts, NCLN mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCLN-associated genes across cancer lineages are p62 Lck ligand, Annexin-1, and Caspase-7-cleavedD198. Each is linked with NCLN in more than 1 cancer types. Because this analysis shows association rather than direction, both NCLN-to-partner and partner-to-NCLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by NCLN-low versus NCLN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCLN→partner) and Y-score (partner→NCLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.466	+2.331	.002	.019	3	1
UCEC	Annexin-1 →	+0.545	+2.189	.026	.034	3	1
UCEC	Caspase-7-cleavedD198 →	+1.243	+2.479	<.001	.010	3	1
UCEC	4E-BP1 →	+0.326	+2.584	.009	.011	3	1
UCEC	ERK2 →	+0.247	+3.321	.005	.010	2	1
UCEC	Caveolin-1 →	+1.393	+3.000	<.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

p62 Lck ligand by NCLN expression — UCEC

Explore this box plot interactively →