NCLN

Across TCGA cell cohorts, NCLN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,104 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NCLN-associated GO terms across cancer lineages are Multi-pass transmembrane protein insertion into ER membrane, Cytoplasm protein quality control by the ubiquitin-proteasome system, and Cytoplasm protein quality control. Each is linked with NCLN in more than 17 cancer types. Because this analysis shows association rather than direction, both NCLN-to-partner and partner-to-NCLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Multi-pass transmembrane protein insertion into ER membrane grouped by NCLN-low versus NCLN-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NCLN→partner) and Y-score (partner→NCLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Multi-pass transmembrane protein insertion into ER membrane →	+0.191	+1.036	<.001	.003	3	18
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.210	+1.064	<.001	<.001	3	16
BONE	Cytoplasm protein quality control →	+0.133	+0.841	.001	<.001	3	15
BLOOD_Lymphoma	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.120	+1.288	<.001	<.001	3	15
URINARY_TRACT	Positive regulation of protein localization to chromatin →	+0.125	+0.691	<.001	<.001	3	12
LARGE_INTESTINE	Regulation of protein localization to chromatin →	+0.107	+0.638	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,104 associations by consensus.

Multi-pass transmembrane protein insertion into ER membrane by NCLN expression — BLOOD_Myeloma

Explore this box plot interactively →