NCLN

Across TCGA cell cohorts, NCLN mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NCLN-associated genes across cancer lineages are PROP1, MYL10, and MYOG. Each is linked with NCLN in more than 1 cancer types. Because this analysis shows association rather than direction, both NCLN-to-partner and partner-to-NCLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by NCLN-low versus NCLN-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCLN→partner) and Y-score (partner→NCLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PROP1 →	+0.019	+4.867	<.001	.009	3	2
BLOOD_Leukemia	MYL10 →	+0.022	+4.984	<.001	.002	3	1
BLOOD_Leukemia	MYOG →	+0.035	+3.769	<.001	.008	3	1
BLOOD_Leukemia	HCN4 →	+0.035	+3.855	.003	.007	3	1
BLOOD_Leukemia	C5orf52 →	+0.022	+4.984	<.001	.002	3	1
BLOOD_Leukemia	CROCC2 →	+0.153	+4.691	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PROP1 by NCLN expression — BLOOD_Lymphoma

Explore this box plot interactively →