NCKAP5

Across TCGA patient cohorts, NCKAP5 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCKAP5-associated genes across cancer lineages are Cyclin-B1, eEF2, and PDCD4. Each is linked with NCKAP5 in more than 5 cancer types. Because this analysis shows association rather than direction, both NCKAP5-to-partner and partner-to-NCKAP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by NCKAP5-low versus NCKAP5-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCKAP5→partner) and Y-score (partner→NCKAP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-B1 →	+0.591	+4.169	<.001	<.001	3	6
STAD	eEF2 →	+0.258	+2.459	.018	.018	3	5
STAD	PDCD4 →	-0.496	-2.700	.001	.005	3	5
STAD	TFRC →	+0.484	+3.000	.032	.033	3	4
SKCM	Bcl-2 →	-0.235	-0.900	.006	.041	3	4
COAD	FASN →	+0.404	+3.584	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

Cyclin-B1 by NCKAP5 expression — STAD

Explore this box plot interactively →