NCKAP1L

Across TCGA patient cohorts, NCKAP1L mutation is significantly associated with the RNA expression of many other genes, with 2,895 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCKAP1L-associated genes across cancer lineages are RPL17P50, MIR181A1, and UHRF1. Each is linked with NCKAP1L in more than 3 cancer types. Because this analysis shows association rather than direction, both NCKAP1L-to-partner and partner-to-NCKAP1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL17P50 grouped by NCKAP1L-low versus NCKAP1L-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCKAP1L→partner) and Y-score (partner→NCKAP1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RPL17P50 →	+0.419	+1.686	.005	.007	3	4
BRCA	MIR181A1 →	+0.327	+4.479	<.001	.007	3	3
UCEC	UHRF1 →	+0.772	+2.098	<.001	<.001	3	3
UCEC	INCENP →	+0.481	+2.145	.002	<.001	3	3
UCEC	H2AZ1 →	+0.518	+1.906	<.001	<.001	3	3
UCEC	CHAF1A →	+0.680	+2.606	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,895 associations by consensus.

RPL17P50 by NCKAP1L expression — LUSC

Explore this box plot interactively →