NCKAP1L

Across TCGA patient cohorts, NCKAP1L mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCKAP1L-associated genes across cancer lineages are MIG-6, p38-MAPK_pT180_Y182, and cIAP. Each is linked with NCKAP1L in more than 3 cancer types. Because this analysis shows association rather than direction, both NCKAP1L-to-partner and partner-to-NCKAP1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by NCKAP1L-low versus NCKAP1L-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCKAP1L→partner) and Y-score (partner→NCKAP1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.097	+2.281	.010	.005	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.357	-1.188	.010	.028	3	3
UCEC	cIAP →	+0.091	+1.331	.032	.043	3	3
UCEC	Cyclin-B1 →	+0.716	+2.169	<.001	<.001	2	4
COAD	G6PD →	+0.149	+1.708	.039	.026	3	2
COAD	NF-kB-p65_pS536 →	-0.573	-2.898	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

MIG-6 by NCKAP1L expression — COAD

Explore this box plot interactively →