NCKAP1L

Across TCGA cell cohorts, NCKAP1L mutation is significantly associated with the RNA expression of many other genes, with 284 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NCKAP1L-associated genes across cancer lineages are SPACA5B, SCML2, and CCNJ. Each is linked with NCKAP1L in more than 1 cancer types. Because this analysis shows association rather than direction, both NCKAP1L-to-partner and partner-to-NCKAP1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPACA5B grouped by NCKAP1L-low versus NCKAP1L-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCKAP1L→partner) and Y-score (partner→NCKAP1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SPACA5B →	+0.073	+5.614	<.001	.002	3	1
LARGE_INTESTINE	SCML2 →	+0.963	+3.212	.008	.006	3	1
LARGE_INTESTINE	CCNJ →	+0.777	+3.212	<.001	.006	3	1
LARGE_INTESTINE	FGF8 →	+0.440	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ZNF330 →	+0.482	+3.212	.008	.006	3	1
LARGE_INTESTINE	BRIX1 →	+0.669	+3.299	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 284 associations by consensus.

SPACA5B by NCKAP1L expression — PANCREAS

Explore this box plot interactively →