NCKAP1

Across TCGA pan-cancer cohorts, NCKAP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NCKAP1 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NCKAP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NCKAP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where NCKAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.319	0.961	.002	27	view →
LUAD	DFS	Quartile	II,III,IV	0.258	0.779	.001	15	view →
HNSC	DFS	Quartile	II,III,IV	0.781	0.489	.011	9	view →
GBM	DFS	Tertile	All	0.816	0.640	.014	8	view →
CCRCC	DFS	Tertile	III,IV	0.830	0.198	.024	3	view →
LSCC	DFS	Quartile	All	1.000	0.896	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NCKAP1–PDAC (DFS)

Open the PDAC breakdown →