NCKAP1

Across TCGA patient cohorts, NCKAP1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCKAP1-associated genes across cancer lineages are FASN, PCNA, and Cyclin-E2. Each is linked with NCKAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NCKAP1-to-partner and partner-to-NCKAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by NCKAP1-low versus NCKAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCKAP1→partner) and Y-score (partner→NCKAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.272	+1.440	.046	.024	3	3
UCEC	PCNA →	+0.253	+2.321	<.001	.005	3	3
UCEC	Cyclin-E2 →	+0.152	+2.070	.009	.001	3	3
UCEC	ATM →	-0.506	-1.736	.001	.007	3	2
UCEC	FoxM1 →	+0.191	+2.070	.033	.001	3	2
UCEC	S6_pS240_S244 →	+0.335	+2.906	.017	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

FASN by NCKAP1 expression — UCEC

Explore this box plot interactively →