NCK2

Across TCGA pan-cancer cohorts, NCK2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NCK2 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NCK2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NCK2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where NCK2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.880	0.334	<.001	30	view →
PDAC	OS	Tertile	All	0.692	0.444	.001	27	view →
LSCC	DFS	Quartile	III,IV	0.219	0.859	.001	13	view →
LUAD	DFS	Quartile	III,IV	0.165	1.000	.008	12	view →
GBM	OS	Quartile	All	0.415	0.623	.018	9	view →
HNSC	DFS	Tertile	IV	0.494	0.843	.003	8	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NCK2–CCRCC (DFS)

Open the CCRCC breakdown →