NCK2

Across TCGA patient cohorts, NCK2 mutation is significantly associated with the RNA expression of many other genes, with 3,269 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCK2-associated genes across cancer lineages are RPL17P50, UBE2SP1, and ALDOA. Each is linked with NCK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NCK2-to-partner and partner-to-NCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL17P50 grouped by NCK2-low versus NCK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCK2→partner) and Y-score (partner→NCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL17P50 →	+0.475	+1.857	<.001	<.001	3	3
UCEC	UBE2SP1 →	+0.541	+1.847	.001	<.001	3	3
UCEC	ALDOA →	+0.466	+2.432	<.001	<.001	3	3
UCEC	SKA1 →	+0.806	+4.108	<.001	<.001	3	3
UCEC	SNRNP25 →	+0.513	+2.190	<.001	<.001	3	3
UCEC	PBK →	+0.943	+2.126	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,269 associations by consensus.

RPL17P50 by NCK2 expression — UCEC

Explore this box plot interactively →