NCK2

Across TCGA cell cohorts, NCK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,558 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NCK2-associated GO terms across cancer lineages are Signal complex assembly, Positive regulation of translation in response to endoplasmic reticulum stress, and Negative regulation of PERK-mediated unfolded protein response. Each is linked with NCK2 in more than 16 cancer types. Because this analysis shows association rather than direction, both NCK2-to-partner and partner-to-NCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Signal complex assembly grouped by NCK2-low versus NCK2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NCK2→partner) and Y-score (partner→NCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Signal complex assembly →	+0.248	+1.185	<.001	<.001	3	17
BONE	Positive regulation of translation in response to endoplasmic reticulum stress →	+0.190	+1.307	<.001	.001	3	16
BONE	Negative regulation of PERK-mediated unfolded protein response →	+0.156	+1.375	<.001	<.001	3	14
BONE	Endosomal transport →	+0.065	+1.314	.009	.006	1	15
BONE	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.136	+1.142	.001	.003	2	14
LUNG_NSCLC_LUAD	Positive regulation of translation in response to stress →	+0.140	+1.090	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,558 associations by consensus.

Signal complex assembly by NCK2 expression — OESOPHAGUS

Explore this box plot interactively →