NCK2

Across TCGA cell cohorts, NCK2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NCK2-associated genes across cancer lineages are GRK7, ACER1, and BPIFA1. Each is linked with NCK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCK2-to-partner and partner-to-NCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRK7 grouped by NCK2-low versus NCK2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCK2→partner) and Y-score (partner→NCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRK7 →	+0.081	+3.374	.004	.005	3	1
LARGE_INTESTINE	ACER1 →	+0.101	+3.145	<.001	.004	3	1
LARGE_INTESTINE	BPIFA1 →	+0.145	+2.688	<.001	.008	3	1
LARGE_INTESTINE	TECRL →	+0.011	+3.240	<.001	.004	3	1
BLOOD_Leukemia	CST8 →	+0.037	+4.384	<.001	.006	3	1
BLOOD_Leukemia	COX6A2 →	+0.223	+4.269	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

GRK7 by NCK2 expression — LARGE_INTESTINE

Explore this box plot interactively →