NCF4

Across TCGA pan-cancer cohorts, NCF4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NCF4 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NCF4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NCF4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

COAD, UCEC, and PDAC are the cancer types where NCF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	III,IV	0.702	1.000	.005	114	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.405	.027	12	view →
PDAC	OS	Tertile	IV	0.231	0.916	.024	7	view →
LUAD	OS	Tertile	II,III,IV	0.902	1.000	.029	5	view →
CCRCC	DFS	Quartile	III,IV	0.233	0.887	.038	3	view →
GBM	OS	Tertile	All	0.284	0.564	.037	2	view →
LSCC	DFS	Median	III,IV	1.000	0.867	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NCF4–COAD (DFS)

Open the COAD breakdown →