NCF4

Across TCGA cell cohorts, NCF4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NCF4-associated genes across cancer lineages are FMO1, C6orf118, and DEFA4. Each is linked with NCF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCF4-to-partner and partner-to-NCF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FMO1 grouped by NCF4-low versus NCF4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCF4→partner) and Y-score (partner→NCF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FMO1 →	+0.129	+3.658	<.001	.005	3	1
LARGE_INTESTINE	C6orf118 →	+0.160	+4.115	<.001	.001	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GPR171 →	+0.017	+3.688	<.001	.002	3	1
LARGE_INTESTINE	RESP18 →	+0.033	+3.632	<.001	.003	3	1
LARGE_INTESTINE	SPRR4 →	+0.102	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FMO1 by NCF4 expression — LARGE_INTESTINE

Explore this box plot interactively →