NCF1

Across TCGA pan-cancer cohorts, NCF1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated NCF1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NCF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NCF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

COAD, PDAC, and UCEC are the cancer types where NCF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	III,IV	0.675	1.000	.016	60	view →
PDAC	OS	Quartile	II,III,IV	0.619	0.995	.008	15	view →
UCEC	OS	Median	II,III,IV	1.000	0.628	.013	8	view →
LSCC	OS	Median	All	0.944	0.817	.026	7	view →
GBM	DFS	Quartile	All	0.655	0.820	.030	4	view →
HNSC	OS	Median	IV	0.835	0.609	.022	4	view →
CCRCC	DFS	Median	II,III,IV	0.960	0.843	.035	2	view →
LUAD	OS	Median	III,IV	0.224	0.625	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

NCF1–COAD (DFS)

Open the COAD breakdown →