NCDN

Across TCGA cell cohorts, NCDN mutation is significantly associated with the RNA expression of many other genes, with 804 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NCDN-associated genes across cancer lineages are USP14, KIF25, and PSMD9. Each is linked with NCDN in more than 1 cancer types. Because this analysis shows association rather than direction, both NCDN-to-partner and partner-to-NCDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP14 grouped by NCDN-low versus NCDN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCDN→partner) and Y-score (partner→NCDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	USP14 →	+0.692	+3.299	.003	.004	3	2
BLOOD_Leukemia	KIF25 →	+0.439	+2.634	<.001	.009	3	2
BLOOD_Leukemia	PSMD9 →	+0.487	+3.199	.009	.007	3	2
BLOOD_Leukemia	KCTD1 →	+1.549	+3.199	<.001	.007	3	2
BLOOD_Leukemia	RNF165 →	+1.130	+3.259	<.001	.006	3	2
LARGE_INTESTINE	CHMP7 →	+0.832	+3.064	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 804 associations by consensus.

USP14 by NCDN expression — LARGE_INTESTINE

Explore this box plot interactively →