NCBP3

Across TCGA patient cohorts, NCBP3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCBP3-associated genes across cancer lineages are Notch1, 14-3-3_beta, and eEF2. Each is linked with NCBP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCBP3-to-partner and partner-to-NCBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by NCBP3-low versus NCBP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCBP3→partner) and Y-score (partner→NCBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.112	+1.375	.009	.020	3	2
UCEC	14-3-3_beta →	-0.122	-3.060	<.001	<.001	3	1
UCEC	eEF2 →	+0.225	+1.064	.040	.048	3	1
UCEC	eIF4E →	+0.148	+1.700	.021	.001	3	1
UCEC	ERK2 →	+0.201	+2.087	<.001	.004	3	1
UCEC	Fibronectin →	-0.324	-1.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Notch1 by NCBP3 expression — UCEC

Explore this box plot interactively →