NCAPH

Across TCGA patient cohorts, NCAPH mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCAPH-associated genes across cancer lineages are TFRC, 4E-BP1, and PDCD4. Each is linked with NCAPH in more than 2 cancer types. Because this analysis shows association rather than direction, both NCAPH-to-partner and partner-to-NCAPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by NCAPH-low versus NCAPH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCAPH→partner) and Y-score (partner→NCAPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.523	+3.700	.003	.001	3	3
UCEC	4E-BP1 →	+0.318	+1.874	<.001	.002	3	3
COAD	PDCD4 →	-0.429	-2.991	.049	.036	3	2
UCEC	ATM →	-0.409	-1.321	.007	.029	3	2
UCEC	Caspase-7-cleavedD198 →	+0.472	+1.785	.017	.007	3	2
UCEC	C-Raf →	+0.165	+2.169	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

TFRC by NCAPH expression — UCEC

Explore this box plot interactively →