NCAPG2

Across TCGA patient cohorts, NCAPG2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCAPG2-associated genes across cancer lineages are eEF2, FoxM1, and ACC1. Each is linked with NCAPG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCAPG2-to-partner and partner-to-NCAPG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by NCAPG2-low versus NCAPG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCAPG2→partner) and Y-score (partner→NCAPG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.360	+2.502	<.001	.001	3	2
UCEC	FoxM1 →	+0.208	+1.241	.006	.015	3	2
UCEC	ACC1 →	+0.263	+1.691	.014	.011	3	2
UCEC	JNK_pT183_Y185 →	-0.191	-1.844	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.112	-2.234	.010	.001	3	2
UCEC	Notch1 →	+0.130	+2.183	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

eEF2 by NCAPG2 expression — UCEC

Explore this box plot interactively →