NCAPD3

Across TCGA patient cohorts, NCAPD3 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCAPD3-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and GAPDH. Each is linked with NCAPD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both NCAPD3-to-partner and partner-to-NCAPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by NCAPD3-low versus NCAPD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCAPD3→partner) and Y-score (partner→NCAPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.290	+2.392	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.631	+1.628	<.001	<.001	3	4
STAD	GAPDH →	+0.419	+3.000	.018	.036	3	3
COAD	Shc_pY317 →	-0.166	-2.450	.023	.020	3	3
COAD	ATM →	-0.615	-2.450	<.001	.020	3	3
COAD	Caspase-7-cleavedD198 →	+1.270	+2.467	<.001	.011	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

4E-BP1 by NCAPD3 expression — UCEC

Explore this box plot interactively →