NCAN

Across TCGA pan-cancer cohorts, NCAN Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated NCAN data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NCAN Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NCAN expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

ACC, LUAD, and UCEC are the cancer types where NCAN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.120	0.772	<.001	30	view →
LUAD	DFS	Median	II,III,IV	0.171	0.664	<.001	29	view →
UCEC	DFS	Median	III,IV	0.915	0.527	.025	16	view →
BLCA	DFS	Median	All	1.000	0.606	.012	16	view →
LUSC	OS	Median	IV	0.001	0.673	.014	13	view →
BRCA	OS	Median	III,IV	0.621	0.906	.007	10	view →
SCLC	DFS	Median	II,III,IV	0.256	0.616	.018	6	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	6	view →
COAD	DFS	Median	II,III,IV	0.128	0.547	.026	3	view →
PRAD	DFS	Median	All	0.780	0.935	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

NCAN–ACC (DFS)

Open the ACC breakdown →