NCAN

Across TCGA patient cohorts, NCAN RNA expression is significantly associated with the go_rna of many other GO terms, with 7,063 significant associations in total. STAD shows the largest number of these associations.

The most reproducible NCAN-associated GO terms across cancer lineages are Microtubule polymerization or depolymerization, Regulation of microtubule-based process, and Protein localization to cytoskeleton. Each is linked with NCAN in more than 15 cancer types. Because this analysis shows association rather than direction, both NCAN-to-partner and partner-to-NCAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule polymerization or depolymerization grouped by NCAN-low versus NCAN-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NCAN→partner) and Y-score (partner→NCAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Microtubule polymerization or depolymerization →	+0.070	+1.420	<.001	.005	2	16
STAD	Regulation of microtubule-based process →	+0.048	+0.109	<.001	<.001	3	15
STAD	Protein localization to cytoskeleton →	+0.062	+0.104	<.001	<.001	3	15
STAD	rRNA transcription →	+0.108	+0.206	<.001	<.001	3	14
STAD	Positive regulation of cell cycle process →	+0.059	+0.139	<.001	<.001	3	14
STAD	Mitochondrial gene expression →	+0.070	+0.105	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,063 associations by consensus.

Microtubule polymerization or depolymerization by NCAN expression — SCLC

Explore this box plot interactively →