NCAN

Across TCGA patient cohorts, NCAN protein abundance is significantly associated with the RNA expression of many other genes, with 5,928 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NCAN-associated genes across cancer lineages are GRIA3, SDCBP, and DIRAS2. Each is linked with NCAN in more than 1 cancer types. Because this analysis shows association rather than direction, both NCAN-to-partner and partner-to-NCAN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NCAN versus GRIA3 in GBM, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCAN→partner) and Y-score (partner→NCAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GRIA3 →	+0.821	+0.503	.002	.002	3	2
UCEC	SDCBP →	-0.472	-1.102	<.001	.001	3	2
UCEC	DIRAS2 →	+1.232	+1.147	.001	.002	3	2
GBM	SNX31 →	+0.774	+0.540	.001	.001	3	2
UCEC	OR9A2 →	+0.750	+1.111	<.001	<.001	3	2
UCEC	LINC02762 →	+1.028	+1.448	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,928 associations by consensus.

NCAN vs GRIA3 — GBM

Explore this scatter interactively →