NCAN

Across TCGA patient cohorts, NCAN mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCAN-associated genes across cancer lineages are c-Jun_pS73, ACC1, and MEK1_p_S217_S221. Each is linked with NCAN in more than 2 cancer types. Because this analysis shows association rather than direction, both NCAN-to-partner and partner-to-NCAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Jun_pS73 grouped by NCAN-low versus NCAN-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCAN→partner) and Y-score (partner→NCAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	c-Jun_pS73 →	-0.193	-3.000	.019	.034	3	3
UCEC	ACC1 →	+0.246	+1.820	.025	.014	3	3
SKCM	MEK1_p_S217_S221 →	+0.143	+1.597	.038	.009	3	3
UCEC	Annexin-1 →	+0.446	+1.382	.005	.021	3	3
UCEC	p62 Lck ligand →	+0.471	+2.273	<.001	<.001	3	3
UCEC	ASNS →	+0.354	+1.736	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

c-Jun_pS73 by NCAN expression — STAD

Explore this box plot interactively →