NCAN

Across TCGA cell cohorts, NCAN RNA expression is significantly associated with the go_rna of many other GO terms, with 1,358 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible NCAN-associated GO terms across cancer lineages are RNA splicing, via transesterification reactions, Cytoplasmic translation, and Positive regulation of DNA repair. Each is linked with NCAN in more than 7 cancer types. Because this analysis shows association rather than direction, both NCAN-to-partner and partner-to-NCAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA splicing, via transesterification reactions grouped by NCAN-low versus NCAN-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NCAN→partner) and Y-score (partner→NCAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RNA splicing, via transesterification reactions →	+0.062	+1.488	<.001	.001	3	8
LUNG_SCLC	Cytoplasmic translation →	+0.080	+1.503	.003	.004	3	7
LUNG_SCLC	Positive regulation of DNA repair →	+0.065	+1.518	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Positive regulation of translation →	+0.062	+0.045	<.001	.001	3	7
LUNG_SCLC	Protein-DNA complex assembly →	+0.063	+1.662	.001	<.001	3	7
LUNG_SCLC	Positive regulation of monoatomic ion transmembrane transport →	-0.084	-1.624	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,358 associations by consensus.

RNA splicing, via transesterification reactions by NCAN expression — LUNG_SCLC

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