NCAN

Across TCGA cell cohorts, NCAN mutation is significantly associated with the RNA expression of many other genes, with 1,581 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NCAN-associated genes across cancer lineages are LMX1A, GKN1, and TEX50. Each is linked with NCAN in more than 2 cancer types. Because this analysis shows association rather than direction, both NCAN-to-partner and partner-to-NCAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LMX1A grouped by NCAN-low versus NCAN-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCAN→partner) and Y-score (partner→NCAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LMX1A →	+0.029	+3.714	<.001	.006	3	2
LUNG_NSCLC_LUAD	GKN1 →	+0.234	+3.565	<.001	.007	3	2
SOFT_TISSUE	TEX50 →	+0.016	+4.392	<.001	.004	3	2
STOMACH	AADACL3 →	+0.377	+2.695	<.001	.009	3	2
OVARY	FAM83C →	+0.130	+3.622	.003	.003	2	3
LARGE_INTESTINE	ABHD5 →	+0.585	+3.850	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,581 associations by consensus.

LMX1A by NCAN expression — BLOOD_Lymphoma

Explore this box plot interactively →