NCAN

Across TCGA cell cohorts, NCAN mutation is significantly associated with the mutation status of many other genes, with 7,025 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NCAN-associated genes across cancer lineages are DIP2C, MEGF8, and ATP10B. Each is linked with NCAN in more than 5 cancer types. Because this analysis shows association rather than direction, both NCAN-to-partner and partner-to-NCAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DIP2C grouped by NCAN-low versus NCAN-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCAN→partner) and Y-score (partner→NCAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DIP2C →	+3.425	+3.204	<.001	<.001	1	6
LARGE_INTESTINE	MEGF8 →	+2.096	+2.516	<.001	<.001	1	5
OVARY	ATP10B →	+3.688	+3.023	.002	.002	1	5
OVARY	PCDHA11 →	+5.009	+3.667	<.001	<.001	1	5
LARGE_INTESTINE	LRP10 →	+4.129	+2.321	.001	.001	1	5
BLOOD_Leukemia	IGSF10 →	+2.111	+2.156	.004	.004	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,025 associations by consensus.

DIP2C by NCAN expression — OVARY

Explore this box plot interactively →