NCAM1

Across TCGA patient cohorts, NCAM1 mutation is significantly associated with the total protein of many other genes, with 104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCAM1-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and Chk1. Each is linked with NCAM1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NCAM1-to-partner and partner-to-NCAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NCAM1-low versus NCAM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCAM1→partner) and Y-score (partner→NCAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.538	-1.917	<.001	<.001	3	5
COAD	Caspase-7-cleavedD198 →	+0.831	+2.459	.005	.018	3	4
LUAD	Chk1 →	+0.406	+3.321	<.001	.009	3	3
LUAD	c-Met_pY1235 →	+0.222	+3.472	<.001	.002	3	3
UCEC	Lck →	+0.147	+1.247	.007	.041	3	3
UCEC	4E-BP1_pT70 →	+0.070	+1.392	.027	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 104 associations by consensus.

ATM by NCAM1 expression — UCEC

Explore this box plot interactively →