Across TCGA pan-cancer cohorts, NBR1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NBR1 data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NBR1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NBR1 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

KIRC, SKCM, and PRAD are the cancer types where NBR1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.116	0.813	<.001	44	view →
SKCM	DFS	Median	All	0.153	0.761	<.001	18	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
COAD	OS	Median	II,III,IV	0.168	0.788	.005	6	view →
BLCA	DFS	Median	II,III,IV	0.823	0.322	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: NBR1 tumor-vs-normal RNA expression · all NBR1 data types