Across TCGA patient cohorts, NBR1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NBR1-associated genes across cancer lineages are EGFR_pY1068, TFRC, and 4E-BP1_pT37_T46. Each is linked with NBR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NBR1-to-partner and partner-to-NBR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBR1→partner) and Y-score (partner→NBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.286	-2.807	.001	.003	3	2
UCEC	TFRC →	+0.437	+3.169	.022	.018	3	2
UCEC	4E-BP1_pT37_T46 →	-0.300	-1.584	.026	.019	3	2
UCEC	EGFR →	-0.171	-2.000	.003	.030	3	1
UCEC	A-Raf_pS299 →	-0.112	-2.584	.009	.010	3	1
UCEC	ERK2 →	+0.212	+2.700	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

NBR1 survival (RNA) · tumor vs normal (RNA) · all NBR1 data types