Across TCGA cell cohorts, NBR1 mutation is significantly associated with the RNA expression of many other genes, with 447 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NBR1-associated genes across cancer lineages are GPR31, FMO1, and ALDH6A1. Each is linked with NBR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NBR1-to-partner and partner-to-NBR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBR1→partner) and Y-score (partner→NBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR31 →	+0.016	+4.906	<.001	.006	3	2
BLOOD_Lymphoma	FMO1 →	+0.615	+3.554	.001	.007	3	2
BLOOD_Leukemia	ALDH6A1 →	+0.599	+3.199	.007	.007	3	2
UPPER_AERODIGESTIVE_TRACT	PABPC1L2B →	+0.099	+4.736	.009	.009	3	2
PANCREAS	GUCY2F →	+0.023	+3.700	<.001	.008	3	1
PANCREAS	SPACA5B →	+0.044	+4.029	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 447 associations by consensus.

Exploration

NBR1 survival (RNA) · tumor vs normal (RNA) · all NBR1 data types