NBPF15

Across TCGA patient cohorts, NBPF15 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NBPF15-associated genes across cancer lineages are FOXO3a_pS318_S321, 4E-BP1_pT37_T46, and Acetyl-a-Tubulin-Lys40. Each is linked with NBPF15 in more than 1 cancer types. Because this analysis shows association rather than direction, both NBPF15-to-partner and partner-to-NBPF15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by NBPF15-low versus NBPF15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBPF15→partner) and Y-score (partner→NBPF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.152	-2.690	.004	.006	3	2
UCEC	4E-BP1_pT37_T46 →	-0.606	-2.906	<.001	.001	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.429	+1.700	.047	.044	3	1
UCEC	JNK_pT183_Y185 →	-0.190	-2.000	.007	.030	3	1
UCEC	JNK2 →	+0.249	+3.026	.003	.018	3	1
UCEC	MEK1 →	+0.511	+2.906	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

FOXO3a_pS318_S321 by NBPF15 expression — UCEC

Explore this box plot interactively →