NBN

Across TCGA pan-cancer cohorts, NBN mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NBN data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NBN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NBN expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where NBN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	II,III,IV	0.831	0.166	<.001	49	view →
HNSC	OS	Tertile	III,IV	0.775	0.977	.001	27	view →
CCRCC	DFS	Tertile	All	0.710	0.915	.017	13	view →
COAD	DFS	Tertile	All	1.000	0.923	.046	12	view →
PDAC	DFS	Tertile	IV	0.934	0.203	.024	6	view →
UCEC	DFS	Tertile	All	1.000	0.934	.049	2	view →
GBM	DFS	Median	All	0.315	0.217	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NBN–LUAD (DFS)

Open the LUAD breakdown →