NBN

Across TCGA patient cohorts, NBN mutation is significantly associated with the RNA expression of many other genes, with 3,708 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NBN-associated genes across cancer lineages are MIR4797, RPS29P32, and RNU6-492P. Each is linked with NBN in more than 2 cancer types. Because this analysis shows association rather than direction, both NBN-to-partner and partner-to-NBN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4797 grouped by NBN-low versus NBN-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBN→partner) and Y-score (partner→NBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR4797 →	+0.790	+5.054	<.001	.001	3	3
UCEC	RPS29P32 →	+0.349	+1.883	<.001	.004	3	3
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	2
READ	RNU6-855P →	+0.498	+4.925	<.001	.004	3	2
READ	XGY1 →	+0.202	+5.681	<.001	.001	3	2
READ	RNU6-781P →	+0.628	+4.925	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,708 associations by consensus.

MIR4797 by NBN expression — READ

Explore this box plot interactively →