NBN

Across TCGA patient cohorts, NBN mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NBN-associated genes across cancer lineages are ATM, eEF2, and EGFR_pY1068. Each is linked with NBN in more than 1 cancer types. Because this analysis shows association rather than direction, both NBN-to-partner and partner-to-NBN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NBN-low versus NBN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBN→partner) and Y-score (partner→NBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.374	-1.362	.019	.037	3	2
UCEC	eEF2 →	+0.292	+2.321	.020	.033	3	1
UCEC	EGFR_pY1068 →	-0.324	-2.874	<.001	<.001	3	1
UCEC	EGFR →	-0.197	-3.433	<.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.118	-2.115	.005	.017	3	1
UCEC	ERK2 →	+0.207	+1.906	.002	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ATM by NBN expression — UCEC

Explore this box plot interactively →