NBN

Across TCGA cell cohorts, NBN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,245 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NBN-associated GO terms across cancer lineages are Blastocyst growth, Double-strand break repair via alternative nonhomologous end joining, and DNA strand elongation. Each is linked with NBN in more than 18 cancer types. Because this analysis shows association rather than direction, both NBN-to-partner and partner-to-NBN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Blastocyst growth grouped by NBN-low versus NBN-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NBN→partner) and Y-score (partner→NBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Blastocyst growth →	+0.259	+1.335	<.001	.001	3	19
LUNG_NSCLC_LUSC	Double-strand break repair via alternative nonhomologous end joining →	+0.145	+1.279	<.001	.002	3	14
LUNG_NSCLC_LUSC	DNA strand elongation →	+0.149	+1.037	.002	.004	3	13
BREAST	Somatic cell DNA recombination →	+0.082	+1.132	<.001	.002	3	12
SKIN	Somatic recombination of immunoglobulin gene segments →	+0.086	+0.804	<.001	<.001	3	12
BREAST	Somatic diversification of immune receptors via germline recombination within a single locus →	+0.082	+1.132	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,245 associations by consensus.

Blastocyst growth by NBN expression — BLOOD_Myeloma

Explore this box plot interactively →