NBN

Across TCGA cell cohorts, NBN mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NBN-associated genes across cancer lineages are C9orf92, OR10K2, and PABPC1L2A. Each is linked with NBN in more than 1 cancer types. Because this analysis shows association rather than direction, both NBN-to-partner and partner-to-NBN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by NBN-low versus NBN-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBN→partner) and Y-score (partner→NBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C9orf92 →	+0.167	+4.212	<.001	<.001	3	2
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1
BREAST	OR10T2 →	+0.183	+5.781	<.001	.001	3	1
LUNG_NSCLC_LUAD	CD2 →	+0.038	+2.781	<.001	.008	3	1
LUNG_NSCLC_LUAD	CETN1 →	+0.005	+3.681	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

C9orf92 by NBN expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →