NBL1

Across TCGA patient cohorts, NBL1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NBL1-associated genes across cancer lineages are GAPDH, EGFR_pY1068, and eIF4E. Each is linked with NBL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NBL1-to-partner and partner-to-NBL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by NBL1-low versus NBL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBL1→partner) and Y-score (partner→NBL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.590	+3.169	.014	.018	3	2
UCEC	EGFR_pY1068 →	-0.291	-3.169	.010	.018	3	1
UCEC	eIF4E →	+0.197	+3.013	.038	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.163	-2.449	.003	.019	3	1
UCEC	INPP4B →	-0.321	-3.169	.027	.018	3	1
UCEC	MEK1 →	+0.391	+3.169	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

GAPDH by NBL1 expression — UCEC

Explore this box plot interactively →