NBEAL2

Across TCGA pan-cancer cohorts, NBEAL2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NBEAL2 data layer compared with 20 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NBEAL2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NBEAL2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

COAD, PDAC, and LUAD are the cancer types where NBEAL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.867	1.000	.032	24	view →
PDAC	OS	Median	IV	0.381	0.951	.006	10	view →
LUAD	OS	Quartile	II,III,IV	0.361	0.861	.043	6	view →
LSCC	DFS	Median	III,IV	1.000	0.867	.045	1	view →
HNSC	OS	Quartile	IV	0.906	0.603	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NBEAL2–COAD (DFS)

Open the COAD breakdown →